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  • 475473-26-8 br enhance sensitivity of chemotherapeutic agent


    enhance sensitivity of chemotherapeutic agents.
    5. Conclusion
    Co-delivery of DOX and SC by NLC-RGD is an appropriate approach to overcome MDR problems of DOX. Results of this study suggested that loading of SC and DOX into NLC-RGD prepare them more effective in accumulation into cancerous cells due to specialized endocytosis which mediated by RGD adhesion to integrins. This study also revealed that SC enhances DOX induced apoptosis by reversing ABC-transporter–me-diated MDR and downregulation of Nrf2 and ABCC1. Therefore, co-delivery of SC and chemotherapeutic agents by NLC-RGD can be con-sidered as a significant method to overcome MDR in cancer treatment.
    The authors would like to thank from the “Clinical Research Development Center of Baqiyatallah hospital” for their kindly co-operation and Faculty of Advanced Medical Sciences of Tabriz University of medical sciences for their kind assistance.
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    Genes & Diseases xxx (xxxx) xxx
    Available online at
    ARHGEF38 as a novel biomarker to predict aggressive prostate cancer
    Kun Liu a, Aixiang Wang b, Longke Ran c, Wanfeng Zhang c, Song Jing c, Yujing Wang a, Xianqin Zhang a, Geli Liu a, Wang Sen a, Fangzhou Song a,*
    a Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China
    b Tianjin Key Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, 300162, Tianjin, China
    c Department of Bioinformatics, Chongqing Medical University, Chongqing, 400016, China
    Gleason score;
    Abstract Prostate cancer (PCa) metastasis is considered the leading cause of cancer death in males. Therapeutic strategies and diagnosis for stage-specific PCa have not been well under-stood. Rho guanine nucleotide exchange factor 38 (ARHGEF38) is related to tumor cell polar-ization and is frequently expressed in PCa. Microarray data of PCa were downloaded from GEO and TCGA databases. A total of 243 DEGs were screened, of which, 32 genes were upregulated. The results of enrichment analysis showed the participation of these DEGs in the tumor cell metastasis pathway. ARHGEF38 was significantly up-regulated in the four most prevalent can-cers worldwide (p < 0.05), and its expression was higher in the tumor samples with higher Gleason score (GS). IHC, qRT-PCR, and western-blot analyses showed the higher expression of ARHGEF38 in PCa than benign prostatic hyperplasia (BPH). In addition, IHC results demon-strated a higher expression of ARHGEF38 in high-grade PCa than the low-grade PCa.
    Copyright ª 2019, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( by-nc-nd/4.0/).
    * Corresponding author.
    E-mail address: [email protected] (F. Song).
    Peer review under responsibility of Chongqing Medical University.
    2352-3042/Copyright ª 2019, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (